Lactobacillus reuteri ATCC PTA 6475 and Reduced Bone Loss

• Lactobacillus reuteri reduces bone loss in older women with low bone mineral density: a randomized, placebo‐controlled, double‐blind, clinical trial

  • 2018-07-22
  • RCT
  • Journal of Internal Medicine 284(3)
  • • Anna G. Nilsson
    • Anna G. Nilsson
    • D. Sundh
    • Fredrik Bäckhed
    • Fredrik Bäckhed
    • M. Lorentzon
    • M. Lorentzon

  • PubMed: 29926979
  • DOI: 10.1111/joim.12805

  1 Insight on

  • Reduced Bone Loss

  • High evidence
  • Highly Cited

  L. reuteri 6475 reduced loss of total vBMD compared to placebo both in the intention-to-treat (ITT) analysis [-0.83% (95% confidence interval [CI], -1.47 to -0.19%) vs. -1.85% (95% CI, -2.64 to -1.07%); mean difference 1.02% (95% CI, 0.02-2.03)] and per protocol analysis [-0.93% (95% CI, -1.45 to -0.40) vs. -1.86% (95% CI, -2.35 to -1.36); mean difference 0.93% (95% CI, 0.21-1.65)].

  Effect

  Beneficial

  Effect size

  Moderate

  Significant

  Yes

  Dose

  10^10 colony-forming units daily

• One-year supplementation with Lactobacillus reuteri ATCC PTA 6475 counteracts a degradation of gut microbiota in older women with low bone mineral density.

  • 2022-10-19
  • RCT · n = 20
  • NPJ biofilms and microbiomes 8(1)
  • • Peishun Li
    • Boyang Ji
    • Hao Luo
    • Daniel Sundh
    • Mattias Lorentzon
    • Jens Nielsen

  • PubMed: 36261538
  • DOI: 10.1038/s41522-022-00348-2

  4 Insights on

  • Reduced Bone Loss

  • High evidence

  In a randomized controlled trial (RCT) we demonstrated that supplementation of Lactobacillus reuteri ATCC PTA 6475 reduced bone loss in older women with low bone mineral density.

  Effect

  Beneficial

  Effect size

  Moderate