Randomised double blind placebo controlled trial on Lactobacillus reuteri DSM 17938: improvement in symptoms and bowel habit in functional constipation.
- 2018-01-29
- RCT · n = 56
- Beneficial Microbes 9(1)
- G. Riezzo
- A. Orlando
- B. D’Attoma
- M. Linsalata
- M. Martulli
- F. Russo
- PubMed: 29022390
- DOI: 10.3920/BM2017.0049
- High evidence
the beneficial effect of LR DSM 17938 compared to placebo was significantly evident for symptoms related to gas content and dysbiosis (abdominal discomfort, pain and bloating), incomplete defecation and helps for defecation (P<0.05)
- Effect
- Beneficial
- Effect size
- Small
- Significant
- Yes
- Dose
- 4×10^8 cfu (induction, days 1-15), then 2×10^8 cfu (maintenance, days 16-105)