Randomised double blind placebo controlled trial on Lactobacillus reuteri DSM 17938: improvement in symptoms and bowel habit in functional constipation.
- 2018-01-29
- RCT · n = 56
- Beneficial Microbes 9(1)
- G. Riezzo
- A. Orlando
- B. D’Attoma
- M. Linsalata
- M. Martulli
- F. Russo
- PubMed: 29022390
- DOI: 10.3920/BM2017.0049
- High evidence
the beneficial effect of LR DSM 17938 compared to placebo was significantly evident for symptoms related to gas content and dysbiosis (abdominal discomfort, pain and bloating)
- Effect
- Beneficial
- Effect size
- Small
- Significant
- Yes
- Dose
- 4×10^8 cfu (induction, days 1-15), then 2×10^8 cfu (maintenance, days 16-105)