Lactobacillus reuteri DSM 17938 and Reduced Fecal Metabolite Levels

• Lactobacillus reuteri DSM 17938 alleviates d-galactosamine-induced liver failure in rats.

  • 2021-01
  • Clinical Trial
  • Biomedicine & Pharmacotherapy 133
  • • Huiyong Jiang
    • Ren Yan
    • Kaicen Wang
    • Qiangqiang Wang
    • Xiaoxiao Chen
    • Lifeng Chen
    • Lanjuan Li
    • L. Lv

  • PubMed: 33202285
  • DOI: 10.1016/j.biopha.2020.111000

  7 Insights on

  • Reduced Fecal Metabolite Levels

  • Low evidence
  • Rigorous Journal
  • Animal Study

  Furthermore, DSM 17938 reduced the d-galactosamine-induced increase in not only fecal metabolites such as trisaminol and lithocholic acid but also the transcription of liver inflammatory genes, such as Ccl2, Ccl7, Ccl11, Ccl12, Il6, Il11, Il20rb, Mmp3 and Mmp10.

  Effect

  Beneficial

  Effect size

  Moderate