Lactobacillus reuteri DSM 17938 and Reduced Proinflammatory Signaling

• Lactobacillus reuteri DSM 17938 alleviates d-galactosamine-induced liver failure in rats.

  • 2021-01
  • Clinical Trial
  • Biomedicine & Pharmacotherapy 133
  • • Huiyong Jiang
    • Ren Yan
    • Kaicen Wang
    • Qiangqiang Wang
    • Xiaoxiao Chen
    • Lifeng Chen
    • Lanjuan Li
    • L. Lv

  • PubMed: 33202285
  • DOI: 10.1016/j.biopha.2020.111000

  7 Insights on

  • Reduced Proinflammatory Signaling

  • Low evidence
  • Rigorous Journal
  • Animal Study

  reduced the elevation in serum... IL-1α, IL-2, IL-18, M-CSF, and MIP-3α levels... [and] reduced the transcription of liver inflammatory genes, such as Ccl2, Ccl7, Ccl11, Ccl12, Il6, Il11, Il20rb, Mmp3 and Mmp10.

  Effect

  Beneficial

  Effect size

  Moderate