Microbial allies in skin trauma recovery: from immune modulation to engineered probiotic therapeutics.
- 2025-10-23
- Review
- Burns & trauma 14
- Aline Yen Ling Wang
- Ana Elena Aviña
- Yen-Yu Liu
- Huang-Kai Kao
- PubMed: 41550964
- DOI: 10.1093/burnst/tkaf068
- Low evidence
Recent genetically engineered Lactobacillus reuteri strains that express chemokines like CXCL12 have been found to promote wound healing to an accelerated rate in animal models, and pre-clinical phases of clinical trials in the setting of diabetic foot ulcers (DFU) has demonstrated safety and therapeutic potential.
- Effect
- Beneficial
- Effect size
- Moderate