Lactobacillus reuteri MAK02L14R and Improved Bile Acid Metabolism

• Lactobacillus reuteri J1 prevents obesity by altering the gut microbiota and regulating bile acid metabolism in obese mice.

  • 2022-06-22
  • Clinical Trial
  • Food & Function 13(12)
  • • Chenxi Zhang
    • Ru-Ying Fang
    • Xing Lu
    • Yu Zhang
    • Mo Yang
    • Yue Su
    • Yujun Jiang
    • C. Man

  • PubMed: 35647914
  • DOI: 10.1039/d1fo04387k

  10 Insights on

  • Improved Bile Acid Metabolism

  • Low evidence
  • Animal Study

  More importantly, mice treated with L. reuteri J1 altered the gut microbiota and bile acid (BA) composition. Analysis of the gut microbiome showed that L. reuteri J1 increased the relative abundances of Lactobacillus, Akkermansia and Clostridium, which strongly correlated with ursodeoxycholic acid (UDCA) and lithocholic acid (LCA).

  Effect

  Beneficial

  Effect size

  Moderate