Lactobacillus reuteri MAK02L14R and Reduced Hepatic Triglyceride Levels

• Lactobacillus reuteri J1 prevents obesity by altering the gut microbiota and regulating bile acid metabolism in obese mice.

  • 2022-06-22
  • Clinical Trial
  • Food & Function 13(12)
  • • Chenxi Zhang
    • Ru-Ying Fang
    • Xing Lu
    • Yu Zhang
    • Mo Yang
    • Yue Su
    • Yujun Jiang
    • C. Man

  • PubMed: 35647914
  • DOI: 10.1039/d1fo04387k

  10 Insights on

  • Reduced Hepatic Triglyceride Levels

  • Low evidence
  • Animal Study

  Consistent with the increase in the BA pool, L. reuteri J1 treatment inhibited the ileum FXR/FGF15 signaling pathway but activated the hepatic FXR/SHP signaling pathway, resulting in reduced hepatic triglyceride accumulation.

  Effect

  Beneficial

  Effect size

  Large