Lactobacillus reuteri Osfortis and Reduced T-Effector Memory Cell Activity

• A bioengineered probiotic for the oral delivery of a peptide Kv1.3 channel blocker to treat rheumatoid arthritis.

  • 2023-01-03
  • Proceedings of the National Academy of Sciences of the United States of America 120(2)
  • • Yuqing Wang
    • Duolong Zhu
    • Laura C Ortiz-Velez
    • Jacob L Perry
    • Michael W Pennington
    • Joseph M Hyser
    • Robert A Britton
    • Christine Beeton

  • PubMed: 36595694
  • DOI: 10.1073/pnas.2211977120

  2 Insights on

  • Reduced T-Effector Memory Cell Activity

  • Low evidence

  preferentially inhibit human T effector memory (TEM) lymphocyte proliferation in vitro

  Effect

  Beneficial

  Effect size

  Moderate