Effects of oral probiotic supplements on vaginal microbiota during pregnancy: a randomised, double-blind, placebo-controlled trial with microbiome analysis.
- 2019-04
- RCT
- BJOG : an international journal of obstetrics and gynaecology 127(2)
- S Husain
- J Allotey
- Z Drymoussi
- M Wilks
- B M Fernandez-Felix
- A Whiley
- J Dodds
- S Thangaratinam
- C McCourt
- E M Prosdocimi
- W G Wade
- B M de Tejada
- J Zamora
- K Khan
- M Millar
- PubMed: 30932317
- DOI: 10.1111/1471-0528.15675
- High evidence
- Pregnant Women
The rates of BV did not differ between groups at 18-20 weeks' gestation (15% (19/123) in the probiotic group vs. 9% (10/115) in the placebo group, adjusted odds ratio 1.82, 95% confidence interval 0.64-5.19).
- Effect
- Neutral
- Effect size
- Small
- Significant
- No
- Dose
- 2.5 × 10^9 colony-forming units (CFUs) once daily