Intake of Lactobacillus reuteri Improves Incretin and Insulin Secretion in Glucose-Tolerant Humans: A Proof of Concept
- 2015-06-17
- RCT · n = 21
- Diabetes Care 38(10)
- M. Simon
- K. Strassburger
- B. Nowotny
- H. Kolb
- P. Nowotny
- V. Burkart
- F. Zivehe
- J. Hwang
- P. Stehle
- G. Pacini
- B. Hartmann
- J. Holst
- C. Mackenzie
- L. Bindels
- I. Martínez
- J. Walter
- B. Henrich
- N. Schloot
- M. Roden
- PubMed: 26084343
- DOI: 10.2337/dc14-2690
- High evidence
- Highly Cited
In glucose-tolerant volunteers, daily administration of L. reuteri SD5865 increased glucose-stimulated GLP-1 and GLP-2 release by 76% (P < 0.01) and 43% (P < 0.01), respectively, compared with placebo.
- Effect
- Beneficial
- Effect size
- Moderate
- Significant
- Yes