Lactobacillus reuteri UALre-16 and Reduced Intestinal Inflammation

• Lactobacillus reuteri Ameliorates Intestinal Inflammation and Modulates Gut Microbiota and Metabolic Disorders in Dextran Sulfate Sodium-Induced Colitis in Mice

  • 2020-07-31
  • Clinical Trial
  • Nutrients 12(8)
  • • Gang Wang
    • Shuo Huang
    • S. Cai
    • Haitao Yu
    • Yuming Wang
    • Xiangfang Zeng
    • S. Qiao

  • PubMed: 32751784
  • DOI: 10.3390/nu12082298

  2 Insights on

  • Reduced Intestinal Inflammation

  • Low evidence
  • Animal Study

  Pretreatment with L. reuteri I5007 effectively relieves inflammation in HT-29 cells challenged with lipopolysaccharide. In vivo, mice were given L. reuteri I5007 by gavage throughout the study, starting one week prior to dextran sulfate sodium (DSS) treatment for one week followed by two days without DSS. L. reuteri I5007 improved DSS-induced colitis, which was confirmed by reduced weight loss, colon length shortening, and histopathological damage, restored the mucus layer, as well as reduced pro-inflammatory cytokines levels.

  Effect

  Beneficial

  Effect size

  Large