Lactobacillus reuteri UALre-16 and Worsened Autoimmune Manifestations

• A Diet-Sensitive Commensal Lactobacillus Strain Mediates TLR7-Dependent Systemic Autoimmunity.

  • 2019-01
  • Clinical Trial
  • Cell Host & Microbe 25(1)
  • • Daniel F. Zegarra-Ruiz
    • Asmaa El Beidaq
    • A. Iñiguez
    • Martina Lubrano di Ricco
    • S. Manfredo Vieira
    • W. Ruff
    • Derek L Mubiru
    • Rebecca L. Fine
    • John A. Sterpka
    • T. Greiling
    • C. Dehner
    • M. Kriegel

  • PubMed: 30581114
  • DOI: 10.1016/j.chom.2018.11.009

  1 Insight on

  • Worsened Autoimmune Manifestations

  • Low evidence
  • Highly Cited
  • Animal Study

  L. reuteri colonization worsened autoimmune manifestations under specific-pathogen-free and gnotobiotic conditions, notably increasing plasmacytoid dendritic cells (pDCs) and interferon signaling.

  Effect

  Harmful

  Effect size

  Large