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Evidence-Based Supplement Research

Evidence-Based Supplement Research

Lactobacillus reuteri and Improved Quality of Life

Doses used in studies

CFU/day: 100 million (median 100 million, IQR 100 million–100 million) — 1 study

Time to effect

Median: 4.3 weeks · IQR 4.3 weeks–4.3 weeks · Range 4.3 weeks–4.3 weeks — Reported in 1 of 2 studies

Safety in these studies

Overall tolerabilityReported
none of the studies documented serious adverse events associated with the intervention.
from: Effectiveness of Probiotics, Prebiotics, and Symbiotic Supplementation in Cystic Fibrosis

2 of 2 papers

The impact of probiotics on pulmonary, gastrointestinal, and growth outcomes in pediatric cystic fibrosis: a randomized controlled trial.
- 2025-05-28
- RCT · n = 55
- BMC pediatrics 25(1)
- - Parisa Rahmani
  - Pejman Rohani
  - Arian Kariman
  - Farzaneh Motamed
  - Mohammad Reza Modaresi
  - Kambiz Eftekhari
  - Mehri Ayati
  - Mohammad Hassan Sohouli
- PubMed: 40437397
- DOI: 10.1186/s12887-025-05789-0
6 Insights on
- Improved Quality of Life
- High evidence
- Clinical
Based on the findings, the score of the CFQ questionnaire in the intervention group increased significantly in the 4th and 12th week.
Effect
Beneficial
Effect size
Small
Significant
Yes
Dose
10^8 CFU/d
Effectiveness of Probiotics, Prebiotics, and Symbiotic Supplementation in Cystic Fibrosis Patients: A Systematic Review and Meta-Analysis of Clinical Trials.
- 2025-03-12
- Meta-Analysis
- Medicina (Kaunas, Lithuania) 61(3)
- - Freiser Eceomo Cruz Mosquera
  - Claudia Lorena Perlaza
  - Anisbed Naranjo Rojas
  - Saray Murillo Rios
  - Alejandra Carrero Gallego
  - Sara Isabel Fischersworring
  - Juan Sebastián Rodríguez
  - Yamil Liscano
- PubMed: 40142300
- DOI: 10.3390/medicina61030489
6 Insights on
- Improved Quality of Life
- High evidence
- Clinical
no significant differences were observed regarding ... quality of life
Effect
Neutral
Effect size
Small
Significant
No