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Evidence-Based Supplement Research

Evidence-Based Supplement Research

Lactobacillus reuteri and Reduced Clinical Attachment Loss

Time to effect

Median: 7.9 weeks · IQR 5.5 weeks–10.4 weeks · Range 3 weeks–3 months — Reported in 2 of 2 studies

2 of 2 papers

Clinical and microbiological effectiveness of limosilactobacillus reuteri in supportive periodontal therapy: randomized clinical trial.
- 2025-08-26
- RCT
- Clinical oral investigations 29(9)
- - Magda Mensi
  - Eleonora Scotti
  - Silvia Marchetti
  - Annamaria Sordillo
  - Gianluca Garzetti
  - Stefano Calza
  - Mark J Buijs
  - Egija Zaura
  - Bernd W Brandt
- PubMed: 40856866
- DOI: 10.1007/s00784-025-06508-w
6 Insights on
- Reduced Clinical Attachment Loss
- High evidence
- Clinical
Both groups showed a significant decrease in PPD, BOP, CAL, and number/percentage of residual pockets compared to baseline. However, no inter-group differences were noted.
Effect
Neutral
Effect size
Small
Significant
No
Dose
3 weeks of bi-daily supplementation with lozenges containing probiotic (specific CFU not stated in abstract)
Impact of Subgingival Lactobacillus reuteri Probiotic Therapy on Clinical Outcomes and Porphyromonas gingivalis Quantification in Peri-Implant Disease: A Prospective RT-PCR-Based Clinical Study.
- 2026
- RCT · n = 26
- Journal of long-term effects of medical implants 36(1)
- - Karthick Kamalakannan
  - Arvina Rajasekar
- PubMed: 41662654
- DOI: 10.1615/jlongtermeffmedimplants.2025060737
5 Insights on
- Reduced Clinical Attachment Loss
- High evidence
- Clinical
Group 2 exhibited significantly greater reductions in PI, GI, PPD, CAL, and P. gingivalis levels compared with Group 1 (P = 0.00)
Effect
Beneficial
Effect size
Large
Significant
Yes
Dose
not specified