Lactobacillus reuteri and Reduced Subgingival Microbial Dysbiosis Index

• Clinical and microbiological effectiveness of limosilactobacillus reuteri in supportive periodontal therapy: randomized clinical trial.

  • 2025-08-26
  • RCT
  • Clinical oral investigations 29(9)
  • • Magda Mensi
    • Eleonora Scotti
    • Silvia Marchetti
    • Annamaria Sordillo
    • Gianluca Garzetti
    • Stefano Calza
    • Mark J Buijs
    • Egija Zaura
    • Bernd W Brandt

  • PubMed: 40856866
  • DOI: 10.1007/s00784-025-06508-w

  7 Insights on

  • Reduced Subgingival Microbial Dysbiosis Index

  • High evidence
  • Clinical

  The subgingival microbial dysbiosis index (SMDI) revealed a decrease in dysbiosis from T0 to T1, followed by a slight increase in dysbiosis towards T3 for both groups. However, no significant differences were noted between the groups.

  Effect

  Neutral

  Effect size

  Small

  Significant

  No

  Dose

  3 weeks of bi-daily supplementation with lozenges containing probiotic (specific CFU not stated in abstract)