Therapeutic effects of Lactobacillus rhamnosus, thymol and their combination against neurotoxicity in propionic acid (PA)-induced autistic rats: insights into the role of the Nrf2/HO-1, Wnt3/β-catenin/GSK3β BDNF/p-TrkB/CREB, pI3K/Akt/mTOR, AMPK/SIRT-1, and PERK/CHOP/Bcl-2 pathways.
- 2026-01-28
- RCT
- Frontiers in pharmacology 16
- Hoda A Salem
- Nermin I Rizk
- Moustafa H AbdelSalam
- Rehab Ahmed
- Hebatallah Husseini Atteia
- Ahmed M E Hamdan
- Areej A Alghamdi
- Manar A Alghusn
- Renad A Alatawi
- Rawan A Atallah
- Maryam M Alfuhaymani
- Hatun A Alqahtani
- Karema Abu-Elfotuh
- PubMed: 41684518
- DOI: 10.3389/fphar.2025.1728908
- High evidence
treatment with L. rhamnosus, Thy and their combination significantly improved the neurobehavioral deficits in the autistic group. Improvements were observed in tests assessing memory consolidation, learning capacity, attention, spatial memory, locomotor activity, and contextual information processing.
- Effect
- Beneficial
- Effect size
- Large
- Significant
- Yes