Lactobacillus rhamnosus HA-11 and Improved Neurotrophic Signaling

• Therapeutic effects of Lactobacillus rhamnosus, thymol and their combination against neurotoxicity in propionic acid (PA)-induced autistic rats: insights into the role of the Nrf2/HO-1, Wnt3/β-catenin/GSK3β BDNF/p-TrkB/CREB, pI3K/Akt/mTOR, AMPK/SIRT-1, and PERK/CHOP/Bcl-2 pathways.

  • 2026-01-28
  • RCT
  • Frontiers in pharmacology 16
  • • Hoda A Salem
    • Nermin I Rizk
    • Moustafa H AbdelSalam
    • Rehab Ahmed
    • Hebatallah Husseini Atteia
    • Ahmed M E Hamdan
    • Areej A Alghamdi
    • Manar A Alghusn
    • Renad A Alatawi
    • Rawan A Atallah
    • Maryam M Alfuhaymani
    • Hatun A Alqahtani
    • Karema Abu-Elfotuh

  • PubMed: 41684518
  • DOI: 10.3389/fphar.2025.1728908

  2 Insights on

  • Improved Neurotrophic Signaling

  • High evidence

  significant upregulation of BDNF, TrkB, CREB, Nrf2, and HO-1 content and downregulation of TLR4/NF-κB-mediated neuroinflammation

  Effect

  Beneficial

  Effect size

  Moderate

  Significant

  Yes