Lactobacillus rhamnosus HA-111 and Reduced Chemotherapy-Induced Diarrhea

• Efficacy and safety of probiotics in preventing chemotherapy-related diarrhea in patients with colorectal cancer: A systematic review and meta-analysis based on 18 randomized trials.

  • 2025-07-04
  • Meta-Analysis · n = 1,526
  • Medicine 104(27)
  • • Meilin Yang
    • Lu Wang
    • Chu Luo
    • Jiarong Shang
    • Xia Zheng
    • Jun Qian
    • Ran Yang

  • PubMed: 40629588
  • DOI: 10.1097/md.0000000000043126

  4 Insights on

  • Reduced Chemotherapy-Induced Diarrhea

  • High evidence

  Meta-analysis demonstrated that probiotics significantly reduced the incidence of diarrhea following chemotherapy in the probiotic group compared to the control group (risk ratio, 0.51; 95% confidence interval: [0.40-0.64]; P = .029).

  Effect

  Beneficial

  Effect size

  Moderate

  Significant

  Yes