Efficacy and safety of probiotic supplements on cognitive function: a systematic review and meta-analysis of randomized clinical trials.
- 2025-11-25
- Meta-Analysis · n = 390
- BMC complementary medicine and therapies 25(1)
- Nancy Calzada-Gonzales
- Ismael Moreno-Colina
- Linn Chu-Fuentes
- Daniel Andrade-Girón
- Hugo E Tito-Chura
- Carlos Quispe-Vicuña
- Pedro I Torres-Balarezo
- Anthony Bautista-Pariona
- Joshuan J Barboza
- PubMed: 41291638
- DOI: 10.1186/s12906-025-05149-6
- High evidence
Limited evidence suggests a possible improvement in cognitive function from probiotics use at 12 weeks (MD 4.23, 95% CI 2.77 to 5.68; certainty of evidence (CoE) was low, I² = 0%) for MMSE and cognitive function (MD 1.21; 95% CI 0.06 to 2.36; certainty of evidence (CoE) was low; I² = 35%) for MoCA; however, due to the very low certainty found, the evidence is very uncertain.
- Effect
- Beneficial
- Effect size
- Small
- Significant
- Yes