Lactobacillus rhamnosus HA-500 and Improved Oral Microbial Balance

• Dual-functional probiotic hydrogel with puerarin integration for microbiota-neuroimmune regulation in antibiotic-free periodontitis therapy.

  • 2025-11
  • Bioactive materials 53
  • • Yi Wang
    • Yansheng Qu
    • Xiangmei Liu
    • Jin Huang
    • Congyang Mao
    • Chaofeng Wang
    • Shengli Zhu
    • Yufeng Zheng
    • Zhaoyang Li
    • Zhenduo Cui
    • Hui Jiang
    • Yang Lv
    • Jie Shen
    • Shuilin Wu

  • PubMed: 40688024
  • DOI: 10.1016/j.bioactmat.2025.07.004

  2 Insights on

  • Improved Oral Microbial Balance

  • Low evidence

  This hydrogel restores the balance of oral microbiota by reducing pathogenic bacteria and promoting probiotic diversity, which helps maintain ecological stability and minimize risks associated with microbial community dysbiosis.

  Effect

  Beneficial

  Effect size

  Moderate