Lactobacillus rhamnosus HA-500 and Increased Cytotoxicity and Mucosal Damage Risk

• Antimicrobial properties and toxicity challenges of chlorine dioxide used in alternative medicine.

  • 2025-05-25
  • Scientific reports 15(1)
  • • Ruth Dudek-Wicher
    • Malwina Brożyna
    • Justyna Paleczny
    • Beata Mączyńska
    • Bartłomiej Dudek
    • Paweł Migdał
    • Arleta Dołowacka-Jóźwiak
    • Jędrzej Fischer
    • Adam Junka

  • PubMed: 40414916
  • DOI: 10.1038/s41598-025-01852-z

  1 Insight on

  • Increased Cytotoxicity and Mucosal Damage Risk

  • Low evidence
  • Rigorous Journal

  Biofilm formed by L. rhamnosus displayed susceptibility to concentrations lower than the minimum biofilm eradication concentration (0.09575%, 957.5 ppm). In the in vitro cytotoxic assay towards eukaryotic fibroblasts and in vivo model of Galleria mellonella larvae concentration-related increase of cytotoxic effects was observed... it implies that ASC applied in humans can lead to damage to the mucous membrane of the gastrointestinal tract.

  Effect

  Harmful

  Effect size

  Moderate