Lactobacillus rhamnosus HN001 and Increased Activation of Regulatory T Cells

• Probiotics Attenuate Food Allergy via Short-Chain Fatty Acids-Mediated Immune Modulation and Gut Barrier Restoration.

  • 2025-11-18
  • Foods (Basel, Switzerland) 14(22)
  • • Xue Feng
    • Liuying Li
    • Li Yan
    • Zhencong Yan
    • Zhoujin Xu
    • Yuting Fan
    • Philippe Madjirebaye
    • Xuli Wu

  • PubMed: 41300111
  • DOI: 10.3390/foods14223953

  5 Insights on

  • Increased Activation of Regulatory T Cells

  • Low evidence

  concurrently enhancing CD4+CD25+ regulatory T cell (Treg) activity and TGF-β1 expression.

  Effect

  Beneficial

  Effect size

  Moderate

• Lactobacillus rhamnosus HN001 Ameliorates BEZ235-Induced Intestinal Dysbiosis and Prolongs Cardiac Transplant Survival

  • 2022-08-31
  • Clinical Trial
  • Microbiology Spectrum 10(4)
  • • Xiaolong Miao
    • Yuancong Jiang
    • Deqiang Kong
    • Zelai Wu
    • Han Liu
    • Xiaolin Ye
    • W. Gong

  • PubMed: 35862958
  • DOI: 10.1128/spectrum.00794-22

  4 Insights on

  • Increased Activation of Regulatory T Cells

  • Low evidence
  • Animal Study

  A main metabolic product of Lactobacillus rhamnosus HN001, propionic acid (PA), enriches regulatory T (Treg) cells and serves as a potent immunomodulatory supplement to BEZ235.

  Effect

  Beneficial

  Effect size

  Moderate