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Evidence-Based Supplement Research
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Lactobacillus rhamnosus HN001 and Reduced Anxiety

Research synthesisModerate evidenceSmall effect4 studies · 3 beneficial · 1 neutral · 0 harmful

Across 4 studies, 3 reported beneficial effects of Lactobacillus rhamnosus HN001 on reduced anxiety, with effect sizes ranging from small to moderate. The strongest evidence comes from a randomized controlled trial in 423 pregnant and postpartum women, which found a significant reduction in clinically relevant anxiety (OR=0.44). The median study duration was 730 days, but this reflects only one study; effects were observed in pregnant and postpartum women, with a smaller neutral study in children.

  • Effective dose range: daily from enrolment until 6 months postpartum if breastfeeding (one study), and daily from 35 weeks gestation until six months if breastfeeding (another study); no consistent dose range across all studies
  • Studied populations: pregnant and postpartum women

Caveats: Available evidence is overwhelmingly positive — clinical literature in this area is subject to publication bias (null-result studies are less likely to be published or indexed). The evidence base is small (only 4 studies) — conclusions should be considered preliminary. One study in children found no significant effect, suggesting benefit may be population-specific.

Generated May 24, 2026
Doses used in studies
  • per day: 1 (median 1, IQR 1–1) — 1 study
Time to effect
Median: 24.3 months · IQR 24.3 months–24.3 months · Range 24.3 months–24.3 months — Reported in 1 of 4 studies
4 of 4 papers
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