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Evidence-Based Supplement Research
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Lactobacillus rhamnosus HN001 and Reduced Anxiety

Research synthesisLow evidenceMixed effect size4 studies · 3 beneficial · 1 neutral · 0 harmful

Across 4 studies, 3 reported beneficial effects of Lactobacillus rhamnosus HN001 on reduced anxiety, with effect sizes ranging from small to moderate. The strongest evidence comes from a 2017 RCT in pregnant and postpartum women (n=423), which found a moderate beneficial effect (OR=0.44, p=0.002) for clinically relevant anxiety. The median study duration across 1 reporting study was 730 days, though effects were observed during pregnancy and postpartum periods rather than long-term follow-up.

  • Effective dose range: daily from enrolment until 6 months postpartum if breastfeeding
  • Studied populations: pregnant and postpartum women

Caveats: Available evidence is overwhelmingly positive — clinical literature in this area is subject to publication bias (null-result studies are less likely to be published or indexed). Evidence base is small (only 4 studies) — conclusions should be considered preliminary. Two studies involve pregnant/postpartum populations, but one of them (2018) found no significant effect on neurocognitive outcomes in children at 11 years, indicating possible lack of long-term anxiety benefit in pediatric populations.

Generated Jul 23, 2026
Doses used in studies
  • per day: 1 (median 1, IQR 1–1) — 1 study
Time to effect
Median: 24.3 months · IQR 24.3 months–24.3 months · Range 24.3 months–24.3 months — Reported in 1 of 4 studies
4 of 4 papers
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