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Evidence-Based Supplement Research
Evidence-Based Supplement Research
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Lactobacillus rhamnosus HN001 and Reduced Anxiety

Research synthesisLow evidenceMixed effect size4 studies · 3 beneficial · 1 neutral · 0 harmful

Across 4 studies, 3 reported beneficial effects of Lactobacillus rhamnosus HN001 on reduced anxiety, with effect sizes ranging from small to moderate. One neutral study found no significant effect. The most-studied population is pregnant and postpartum women, and effects were typically observed over a median study duration of 730 days (2 years) in the one study that reported duration.

  • Studied populations: pregnant women, postpartum women

Caveats: Available evidence is overwhelmingly positive (3 of 4 studies beneficial) — clinical literature in this area is subject to publication bias (null-result studies are less likely to be published or indexed). Evidence base is small (only 4 studies) — conclusions should be considered preliminary. One study in children at risk of allergic disease found no significant effect on neurocognitive outcomes, suggesting that benefit may be population-specific.

Generated Jun 23, 2026
Doses used in studies
  • per day: 1 (median 1, IQR 1–1) — 1 study
Time to effect
Median: 24.3 months · IQR 24.3 months–24.3 months · Range 24.3 months–24.3 months — Reported in 1 of 4 studies
4 of 4 papers
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