Effect of Lactobacillus rhamnosus HN001 in Pregnancy on Postpartum Symptoms of Depression and Anxiety: A Randomised Double-blind Placebo-controlled Trial
- 2017-10
- RCT · n = 423
- EBioMedicine 24
- R. Slykerman
- Fiona Hood
- K. Wickens
- John F. Thompson
- C. Barthow
- R. Murphy
- Janice Kang
- Judy Rowden
- P. Stone
- Julian Crane
- T. Stanley
- P. Abels
- G. Purdie
- Robyn M. Maude
- E. Mitchell
- PubMed: 28943228
- DOI: 10.1016/j.ebiom.2017.09.013
- High evidence
- Large Human Trial
- Highly Cited
- Rigorous Journal
- Pregnant Women
Mothers in the probiotic treatment group reported significantly lower depression scores (HN001 mean=7·7 (SD=5·4), placebo 9·0 (6·0); effect size -1·2, (95% CI -2·3, -0·1), p=0·037)
- Effect
- Beneficial
- Effect size
- Small
- Significant
- Yes
- Dose
- daily from enrolment until 6 months postpartum if breastfeeding