Lactobacillus rhamnosus IMC 501 and Reduced Intestinal Fibrosis

• A bile acid-GPBAR1 network supports anti-inflammatory and anti-fibrotic benefits of probiotics in colitis.

  • 2026-03-18
  • Gut microbes 18(1)
  • • Michele Biagioli
    • Cristina Di Giorgio
    • Silvia Marchianò
    • Benedetta Sensini
    • Ginevra Urbani
    • Eleonora Giannelli
    • Ginevra Lachi
    • Carmen Massa
    • Maria Rosaria Sette
    • Francesca Paniconi
    • Elva Morretta
    • Maria Chiara Monti
    • Angela Zampella
    • Eleonora Distrutti
    • Stefano Fiorucci

  • PubMed: 41851067
  • DOI: 10.1080/19490976.2026.2645125

  2 Insights on

  • Reduced Intestinal Fibrosis

  • Low evidence

  only the 9-strains probiotic attenuates inflammation and fibrosis in chronic colitis.

  Effect

  Beneficial

  Effect size

  Moderate