Lactobacillus rhamnosus LCS-742 and Improved Intestinal Barrier Integrity

• Lactobacillus rhamnosus GG supernatant enhance neonatal resistance to systemic Escherichia coli K1 infection by accelerating development of intestinal defense

  • 2017-03-06
  • Clinical Trial
  • Scientific Reports 7(1)
  • • Xiaolong He
    • Qing Zeng
    • Santhosh Puthiyakunnon
    • Zhijie Zeng
    • Weijun Yang
    • Jiawen Qiu
    • Lei Du
    • S. Boddu
    • Tongwei Wu
    • Danxian Cai
    • Sheng-He Huang
    • Hong-yong Cao

  • PubMed: 28262688
  • DOI: 10.1038/srep43305

  3 Insights on

  • Improved Intestinal Barrier Integrity

  • Low evidence
  • Animal Study

  Our in vitro results showed that LCS could block adhesion, invasion and translocation of E. coli K1 to Caco-2 monolayer via up-regulating mucin production and maintaining intestinal integrity.

  Effect

  Beneficial

  Effect size

  Moderate