Lactobacillus rhamnosus LCS-742 and Reduced Intestinal Oxidative Damage

• Exopolysaccharides produced by Lactobacillus rhamnosus GG alleviate hydrogen peroxide-induced intestinal oxidative damage and apoptosis through the Keap1/Nrf2 and Bax/Bcl-2 pathways in vitro.

  • 2022-01-27
  • Food & Function 12(20)
  • • Jinze Li
    • Qiuke Li
    • Nan Gao
    • Zhihua Wang
    • Feng Li
    • Jianping Li
    • A. Shan

  • PubMed: 34664577
  • DOI: 10.1039/d1fo00277e

  3 Insights on

  • Reduced Intestinal Oxidative Damage

  • Low evidence

  EPSs of LGG could effectively alleviate the IPEC-J2 oxidative damage induced by H2O2 through the Bcl-2-associated (Bax)/B cell lymphoma-2 (Bcl-2) and Kelch-like ECH-associated protein 1 (Keap1)/nuclear factor-erythroid 2-related factor-2 (Nrf2) signaling pathways

  Effect

  Beneficial

  Effect size

  Moderate