Lactobacillus rhamnosus LCS-742 and Reduced Susceptibility to Systemic Escherichia coli K1 Infection

• Lactobacillus rhamnosus GG supernatant enhance neonatal resistance to systemic Escherichia coli K1 infection by accelerating development of intestinal defense

  • 2017-03-06
  • Clinical Trial
  • Scientific Reports 7(1)
  • • Xiaolong He
    • Qing Zeng
    • Santhosh Puthiyakunnon
    • Zhijie Zeng
    • Weijun Yang
    • Jiawen Qiu
    • Lei Du
    • S. Boddu
    • Tongwei Wu
    • Danxian Cai
    • Sheng-He Huang
    • Hong-yong Cao

  • PubMed: 28262688
  • DOI: 10.1038/srep43305

  3 Insights on

  • Reduced Susceptibility to Systemic Escherichia coli K1 Infection

  • Low evidence
  • Animal Study

  In vivo experiments revealed that pre-treatment with LCS significantly decrease susceptibility of neonatal rats to oral E. coli K1 infection as reflected by reduced bacterial intestinal colonization, translocation, dissemination and systemic infections.

  Effect

  Beneficial

  Effect size

  Large

  Significant

  Yes