Lactobacillus rhamnosus LR05 and Accelerated Recovery of Chemotherapy-Induced Myelosuppression

• Improvement of Myelopoiesis in Cyclophosphamide-Immunosuppressed Mice by Oral Administration of Viable or Non-Viable Lactobacillus Strains.

  • 2021-04-12
  • Frontiers in immunology 12
  • • Andrés Gramajo Lopez
    • Florencia Gutiérrez
    • Lucila Saavedra
    • Elvira Maria Hebert
    • Susana Alvarez
    • Susana Salva

  • PubMed: 33912172
  • DOI: 10.3389/fimmu.2021.647049

  2 Insights on

  • Accelerated Recovery of Chemotherapy-Induced Myelosuppression

  • Low evidence
  • Animal Study

  Lr05NV and Lr05V treatments were able to promote early recovery of LSK cells ... and myeloid cells ... with respect to the untreated Cy control... both Lr05V and Lr05NV treatments are able to activate beneficially the IL-17A/GM-CSF axis and accelerate the recovery of Cy-induced immunosuppression by increasing BM myeloid precursors.

  Effect

  Beneficial

  Effect size

  Large