Lactobacillus rhamnosus LR06 and Increased Plasma Serotonin Levels

• Exploring neurotransmitter regulation following probiotic supplementation in adults with subthreshold depression: A secondary analysis of a randomized controlled trial.

  • 2025-12
  • RCT · n = 39
  • Nutrition (Burbank, Los Angeles County, Calif.) 140
  • • Pauline Dacaya
    • Katerina Sarapis
    • Renate Hall
    • Kanny Yim
    • Stephanie Resciniti
    • Antony Vinh
    • Quynh Nhu Dinh
    • Thy Truong
    • Marco Pane
    • Jessica R Biesiekierski
    • George Moschonis

  • PubMed: 40729791
  • DOI: 10.1016/j.nut.2025.112891

  2 Insights on

  • Increased Plasma Serotonin Levels

  • High evidence

  Plasma serotonin concentrations significantly increased at 6 weeks in both probiotic and placebo groups (2.5 (95% CI 1.3; 3.8) and 2.3 (95% CI 1.0; 3.6), respectively) but only in the placebo group (4.9 [95% CI 1.5; 8.3]) at 12 weeks.

  Effect

  Beneficial

  Effect size

  Small

  Significant

  Yes