Lactobacillus rhamnosus LRa05 and Reduced Tumor Necrosis Factor Alpha Doses used in studies
CFU/day: 10 billion (median 10 billion, IQR 10 billion–10 billion) — 1 study Time to effect
Median: 4 weeks · IQR 4 weeks–4 weeks · Range 4 weeks–4 weeks — Reported in 1 of 2 studies
Safety in these studies
Overall tolerability Reported
Although LRa05 did not significantly improve the success rate of H. pylori eradication therapy, it has the potential to improve liver function and reduced levels of inflammatory markers such as IL-6 and TNF-α in the body, regulating the inflammatory response. In addition, it played a positive role in alleviating the adverse symptoms and gut microbiota disturbances caused by eradication therapy, providing a possible way to improve the overall health of patients and demonstrating promising clinical potential.
from: Evaluation of efficacy and safety of Lacticaseibacillus rhamnosus LRa05 in the eradication abdominal pain Reported
GSRS symptom scores showed that LRa05 alleviated abdominal pain, acid reflux, bloating, and diarrhea, enhancing patient compliance.
from: Evaluation of efficacy and safety of Lacticaseibacillus rhamnosus LRa05 in the eradication acid reflux Reported
GSRS symptom scores showed that LRa05 alleviated abdominal pain, acid reflux, bloating, and diarrhea, enhancing patient compliance.
from: Evaluation of efficacy and safety of Lacticaseibacillus rhamnosus LRa05 in the eradication bloating Reported
GSRS symptom scores showed that LRa05 alleviated abdominal pain, acid reflux, bloating, and diarrhea, enhancing patient compliance.
from: Evaluation of efficacy and safety of Lacticaseibacillus rhamnosus LRa05 in the eradication diarrhea Reported
GSRS symptom scores showed that LRa05 alleviated abdominal pain, acid reflux, bloating, and diarrhea, enhancing patient compliance.
from: Evaluation of efficacy and safety of Lacticaseibacillus rhamnosus LRa05 in the eradication 2 of 2 papers Population: All (2) Clinical (1) Unspecified (1)
2024-08-21 RCT Frontiers in immunology 15 Yue Niu Jing Li Hongwei Qian Chunli Liang Xinyi Shi Shurui Bu Significant reductions in neutrophil count, alanine aminotransferase, aspartate aminotransferase, pepsinogen I, interleukin-6 (IL-6), tumor necrosis factor α (TNF-α) (p < 0.05) suggest that LRa05 supplementation may mitigate inflammation
Effect Beneficial Effect size Small Significant Yes Dose 1 × 10^10 CFU/day for 4 weeks 2026-04 RCT · n = 80 Food science & nutrition 14(4) Sijia Zhu Yan Qiao Wenjing He Yaojie Xiao Guiqin Song Kang Liu Shuguang Fang the probiotic intervention led to a significant reduction in the levels of IL-17 and TNF-α (p < 0.05)
Effect Beneficial Effect size Small Significant Yes Dose not stated