Lactobacillus rhamnosus MAK79L08R and Improved Oral Tolerance

• Extensively hydrolyzed casein formula containing Lactobacillus rhamnosus GG reduces the occurrence of other allergic manifestations in children with cow's milk allergy: 3‐year randomized controlled trial

  • 2017-06
  • RCT · n = 220
  • Journal of Allergy and Clinical Immunology 139(6)
  • • R. B. Canani
    • M. Di Costanzo
    • G. Bedogni
    • Antonio Amoroso
    • L. Cosenza
    • C. di Scala
    • V. Granata
    • R. Nocerino

  • PubMed: 28043872
  • DOI: 10.1016/j.jaci.2016.10.050

  6 Insights on

  • Improved Oral Tolerance

  • High evidence
  • Highly Cited
  • Clinical

  The absolute risk difference for the acquisition of cow's milk tolerance was 0.20 (95% CI, 0.05-0.35; P < .01) at 12 months, 0.24 (95% CI, 0.08-0.41; P < .01) at 24 months, and 0.27 (95% CI, 0.11-0.43; P < .001) at 36 months.

  Effect

  Beneficial

  Effect size

  Large

  Significant

  Yes