Lactobacillus rhamnosus PXN 54 and Reduced Painkiller Consumption

• Unravelling the gut-brain connection: a systematic review of migraine and the gut microbiome.

  • 2025-05-21
  • Systematic Review
  • The journal of headache and pain 26(1)
  • • Caroline W Mugo
    • Ella Church
    • Richard D Horniblow
    • Susan P Mollan
    • Hannah Botfield
    • Lisa J Hill
    • Alexandra J Sinclair
    • Olivia Grech

  • PubMed: 40399789
  • DOI: 10.1186/s10194-025-02039-7

  4 Insights on

  • Reduced Painkiller Consumption

  • High evidence

  Synbiotic and synbiotic/probiotic combination treatments have been shown in five randomised controlled trials and one open label pilot study to significantly decrease migraine severity, frequency, duration and painkiller consumption.

  Effect

  Beneficial

  Effect size

  Moderate

  Significant

  Yes