Lactobacillus rhamnosus R0011 and Increased Glycyrrhetinic Acid Bioavailability

• The Effect of Gut Microbiome Perturbation on the Bioavailability of Glycyrrhizic Acid in Rats.

  • 2025-04-01
  • Pharmaceutics 17(4)
  • • Tiantian Shi
    • Huifang Li
    • Zihao Zhang
    • Yuying Zang
    • Shu Jiang
    • Tianjie Yuan

  • PubMed: 40284452
  • DOI: 10.3390/pharmaceutics17040457

  1 Insight on

  • Increased Glycyrrhetinic Acid Bioavailability

  • Low evidence

  R0011 supplementation could significantly increase the Area Under Curve (AUC) value of GA, which was positively correlated with the change in gut microbiome composition.

  Effect

  Beneficial

  Effect size

  Moderate

  Significant

  Yes

• The Bioavailability of Glycyrrhizinic Acid Was Enhanced by Probiotic Lactobacillus rhamnosus R0011 Supplementation in Liver Fibrosis Rats.

  • 2022-12-11
  • Nutrients 14(24)
  • • Huifang Li
    • Jing Wang
    • Yifan Fu
    • Ke Zhu
    • Zhiling Dong
    • Jinjun Shan
    • Liuqing Di
    • Shu Jiang
    • Tianjie Yuan

  • PubMed: 36558437
  • DOI: 10.3390/nu14245278

  2 Insights on

  • Increased Glycyrrhetinic Acid Bioavailability

  • Low evidence
  • Rigorous Journal
  • Animal Study

  Healthy rats supplemented with R0011 could increase the bioavailability of GL by 1.4-fold compared with the normal group... Moreover, the GL bioavailability of MLGG group was significantly increased by 4.5-fold compared with the model group.

  Effect

  Beneficial

  Effect size

  Large

  Significant

  Yes