Lactobacillus rhamnosus R0343ND and Reduced Pro-inflammatory Cytokine Interleukin-8 Levels

• No Evidence of Harms of Probiotic Lactobacillus rhamnosus GG ATCC 53103 in Healthy Elderly—A Phase I Open Label Study to Assess Safety, Tolerability and Cytokine Responses

  • 2014-12-01
  • Clinical Trial · n = 15
  • PLoS ONE 9(12)
  • • P. Hibberd
    • L. Kleimola
    • Anne‐Maria Fiorino
    • Christine Botelho
    • Miriam Haverkamp
    • Irina Andreyeva
    • D. Poutsiaka
    • C. Fraser
    • G. Solano-Aguilar
    • D. Snydman

  • PubMed: 25438151
  • DOI: 10.1371/journal.pone.0113456

  10 Insights on

  • Reduced Pro-inflammatory Cytokine Interleukin-8 Levels

  • High evidence
  • Rigorous Journal

  In the exploratory analysis, the pro-inflammatory cytokine interleukin 8 decreased during LGG consumption, returning towards baseline one month after discontinuing LGG (p = 0.038)...

  Effect

  Beneficial

  Effect size

  Small

  Significant

  Yes