Lactobacillus rhamnosus UALrh-18 and Reduced NEC Severity

• Lactobacillus rhamnosus HN001 decreases the severity of necrotizing enterocolitis in neonatal mice and preterm piglets: evidence in mice for a role of TLR9.

  • 2014-06-01
  • Clinical Trial
  • American Journal of Physiology-Gastrointestinal and Liver Physiology 306(11)
  • • M. Good
    • C. Sodhi
    • J. Ozolek
    • R. Buck
    • Karen C. Goehring
    • Debra L Thomas
    • A. Vikram
    • K. Bibby
    • Michael J. Morowitz
    • B. Firek
    • Peng Lu
    • D. Hackam

  • PubMed: 24742987
  • DOI: 10.1152/ajpgi.00452.2013

  5 Insights on

  • Reduced NEC Severity

  • Low evidence
  • Highly Cited
  • Animal Study
  • Mixed

  We now show that oral administration of live or UV-inactivated Lactobacillus rhamnosus HN001 attenuates NEC severity in newborn mice and premature piglets, as manifest by reduced histology score, attenuation of mucosal cytokine response, and improved gross morphology.

  Effect

  Beneficial

  Effect size

  Large