Lactobacillus rhamnosus and Improved Gastrointestinal Symptoms

Research synthesisLow evidenceModerate effect3 studies · 3 beneficial · 0 neutral · 0 harmful

Across 3 studies, all reported beneficial effects on gastrointestinal symptoms, with effect sizes predominantly moderate (one small, two moderate). However, none of the studies reported statistically significant results. The evidence primarily comes from individuals with autism spectrum disorder (ASD) and a chronically ill oncological cohort, with no consistent dose or form identified.

Studied populations: individuals with autism spectrum disorder (ASD) and chronically ill oncological patients

Caveats: Evidence base is small (only 3 studies) — conclusions should be considered preliminary. Available evidence is overwhelmingly positive — clinical literature in this area is subject to publication bias (null-result studies are less likely to be published or indexed). Many of the included studies did not reach statistical significance — effect may be smaller than the predominant direction suggests.

Generated Jul 12, 2026

3 of 3 papers

Interventions on Microbiota: Where Do We Stand on a Gut-Brain Link in Autism? A Systematic Review.
- 2022-01-20
- Systematic Review · n = 1,769
- Nutrients 14(3)
- - Margherita Prosperi
  - Elisa Santocchi
  - Letizia Guiducci
  - Jacopo Frinzi
  - Maria Aurora Morales
  - Raffaella Tancredi
  - Filippo Muratori
  - Sara Calderoni
- PubMed: 35276821
- DOI: 10.3390/nu14030462
3 Insights on
- Improved Gastrointestinal Symptoms
- High evidence
- Rigorous Journal
This systematic review offers practitioners an overview of the potential therapeutic options to modify dysbiosis, GI symptoms, and ASD severity by modulating the microbiota-gut-brain axis in ASD.
Effect
Beneficial
Effect size
Small
An exploratory study of a multi-species probiotic formulation and markers of health in a real-world oncological cohort in the time of covid.
- 2024-06-26
- Clinical Trial
- Inflammopharmacology 32(4)
- - Michael Thomsen
  - Ravichandra Vemuri
  - Flavia Huygens
  - Stephen Clarke
  - Luis Vitetta
- PubMed: 38926298
- DOI: 10.1007/s10787-024-01503-1
8 Insights on
- Improved Gastrointestinal Symptoms
- Moderate evidence
Improvement in bowel function, with reduction in constipation and or diarrhoea or absence of significant disturbance to bowel function was recorded in 85% of the participants.
Effect
Beneficial
Effect size
Moderate
The Current and Future Perspectives of Postbiotics.
- 2023-02-10
- Review
- Probiotics and antimicrobial proteins 15(6)
- - Bing Liang
  - Dongming Xing
- PubMed: 36763279
- DOI: 10.1007/s12602-023-10045-x
5 Insights on
- Improved Gastrointestinal Symptoms
- Moderate evidence
- Rigorous Journal
consuming Lactobacillus rhamnosus lysate powder
Effect
Beneficial
Effect size
Moderate

Lactobacillus rhamnosus and Improved Gastrointestinal Symptoms

Interventions on Microbiota: Where Do We Stand on a Gut-Brain Link in Autism? A Systematic Review.

An exploratory study of a multi-species probiotic formulation and markers of health in a real-world oncological cohort in the time of covid.

The Current and Future Perspectives of Postbiotics.