Lactobacillus rhamnosus and Improved Gastrointestinal Symptoms

Research synthesisLow evidenceModerate effect3 studies · 3 beneficial · 0 neutral · 0 harmful

Across 3 studies, all reported beneficial effects on gastrointestinal symptoms, predominantly with moderate effect size. The highest-quality study, a systematic review in individuals with autism spectrum disorder, found a small beneficial effect. Limited evidence exists for specific populations such as those with ASD and oncological patients; no consistent dose or form was reported.

Studied populations: people with autism spectrum disorder and individuals undergoing oncological treatment

Caveats: Available evidence is overwhelmingly positive — clinical literature in this area is subject to publication bias (null-result studies are less likely to be published or indexed). Evidence base is small (only 3 studies) — conclusions should be considered preliminary. None of the included studies reported statistical significance — effect may be smaller than the predominant direction suggests. Studies used different populations and lacked standardized reporting of dose, form, and duration.

Generated May 12, 2026

3 of 3 papers

Interventions on Microbiota: Where Do We Stand on a Gut-Brain Link in Autism? A Systematic Review.
- 2022-01-20
- Systematic Review · n = 1,769
- Nutrients 14(3)
- - Margherita Prosperi
  - Elisa Santocchi
  - Letizia Guiducci
  - Jacopo Frinzi
  - Maria Aurora Morales
  - Raffaella Tancredi
  - Filippo Muratori
  - Sara Calderoni
- PubMed: 35276821
- DOI: 10.3390/nu14030462
3 Insights on
- Improved Gastrointestinal Symptoms
- High evidence
- Rigorous Journal
This systematic review offers practitioners an overview of the potential therapeutic options to modify dysbiosis, GI symptoms, and ASD severity by modulating the microbiota-gut-brain axis in ASD.
Effect
Beneficial
Effect size
Small
An exploratory study of a multi-species probiotic formulation and markers of health in a real-world oncological cohort in the time of covid.
- 2024-06-26
- Clinical Trial
- Inflammopharmacology 32(4)
- - Michael Thomsen
  - Ravichandra Vemuri
  - Flavia Huygens
  - Stephen Clarke
  - Luis Vitetta
- PubMed: 38926298
- DOI: 10.1007/s10787-024-01503-1
8 Insights on
- Improved Gastrointestinal Symptoms
- Moderate evidence
Improvement in bowel function, with reduction in constipation and or diarrhoea or absence of significant disturbance to bowel function was recorded in 85% of the participants.
Effect
Beneficial
Effect size
Moderate
The Current and Future Perspectives of Postbiotics.
- 2023-02-10
- Review
- Probiotics and antimicrobial proteins 15(6)
- - Bing Liang
  - Dongming Xing
- PubMed: 36763279
- DOI: 10.1007/s12602-023-10045-x
5 Insights on
- Improved Gastrointestinal Symptoms
- Moderate evidence
- Rigorous Journal
consuming Lactobacillus rhamnosus lysate powder
Effect
Beneficial
Effect size
Moderate

Lactobacillus rhamnosus and Improved Gastrointestinal Symptoms

Interventions on Microbiota: Where Do We Stand on a Gut-Brain Link in Autism? A Systematic Review.

An exploratory study of a multi-species probiotic formulation and markers of health in a real-world oncological cohort in the time of covid.

The Current and Future Perspectives of Postbiotics.