Lactobacillus rhamnosus and Improved Live Biotherapeutic Product Potency and Purity Testing Reagents

• Characterization of Lactobacilli Phage Endolysins and Their Functional Domains-Potential Live Biotherapeutic Testing Reagents.

  • 2023-09-23
  • Viruses 15(10)
  • • Robert J Dorosky
    • Stephanie L Lola
    • Haleigh A Brown
    • Jeremy E Schreier
    • Sheila M Dreher-Lesnick
    • Scott Stibitz

  • PubMed: 37896764
  • DOI: 10.3390/v15101986

  1 Insight on

  • Improved Live Biotherapeutic Product Potency and Purity Testing Reagents

  • Low evidence

  CBDs of the following five lactobacilli phage lysins were characterized... These proteins may be useful LBP potency reagents, and the lytic activity suggests that CL1-lys, jlb1-lys, and ΦJB-lys and their EADs are good candidates for LBP purity reagent development.

  Effect

  Beneficial

  Effect size

  Moderate