Lactobacillus rhamnosus and Improved Skin Barrier Function

Research synthesisLow evidenceMixed effect size4 studies · 4 beneficial · 0 neutral · 0 harmful

Across 4 studies, all reported beneficial effects on skin barrier function, with effect sizes ranging from small to moderate (two studies each). The most robust evidence comes from a 2025 review showing significant improvement in skin moisturization and reduced transepidermal water loss after 4 weeks of Lactobacillus rhamnosus lysate consumption. No specific dose, form, or population data were consistently reported across studies.

Caveats: Available evidence is overwhelmingly positive — clinical literature in this area is subject to publication bias (null-result studies are less likely to be published or indexed). Evidence base is small (only 4 studies) — conclusions should be considered preliminary. Many of the included studies did not reach statistical significance (only 1 of 4) — effect may be smaller than the predominant direction suggests.

Generated Jul 11, 2026

4 of 4 papers

An Integrated Engineering Approach to Creating Health-Modulating Postbiotics.
- 2025-11-17
- Review
- Molecular nutrition & food research 70(1)
- - Michael Leonidas Chikindas
  - Diana E Roopchand
  - Santosh Kumar Tiwari
  - Liubov S Sichel
  - Mukund V Karwe
  - Nitin Nitin
  - Vitor Luis Fagundes
  - Igor V Popov
  - John R Tagg
  - Xuanxuan Lu
  - Svetoslav Dimitrov Todorov
- PubMed: 41251175
- DOI: 10.1002/mnfr.70326
6 Insights on
- Improved Skin Barrier Function
- Moderate evidence
- Rigorous Journal
After 4 weeks of daily consumption of Lactobacillus rhamnosus lysate powder, skin moisturization was improved and transepidermal water loss decreased significantly, indicating enhanced skin barrier function.
Effect
Beneficial
Effect size
Moderate
Significant
Yes
The Current and Future Perspectives of Postbiotics.
- 2023-02-10
- Review
- Probiotics and antimicrobial proteins 15(6)
- - Bing Liang
  - Dongming Xing
- PubMed: 36763279
- DOI: 10.1007/s12602-023-10045-x
5 Insights on
- Improved Skin Barrier Function
- Moderate evidence
- Rigorous Journal
consuming Lactobacillus rhamnosus lysate powder... observed health outcomes... improved skin barrier function and skin moisturization
Effect
Beneficial
Effect size
Moderate
Current Approaches in Cosmeceuticals: Peptides, Biotics and Marine Biopolymers.
- 2025-03-18
- Review
- Polymers 17(6)
- - Ulya Badilli
  - Ozge Inal
- PubMed: 40292641
- DOI: 10.3390/polym17060798
2 Insights on
- Improved Skin Barrier Function
- Low evidence
biotic components are extensively evaluated for their potential to improve barrier function by maintaining the balance of the skin microflora
Effect
Beneficial
Effect size
Small
Probiotics in Cosmetic and Personal Care Products: Trends and Challenges.
- 2021-02-26
- Review
- Molecules (Basel, Switzerland) 26(5)
- - Scarlett Puebla-Barragan
  - Gregor Reid
- PubMed: 33652548
- DOI: 10.3390/molecules26051249
2 Insights on
- Improved Skin Barrier Function
- Low evidence
Lactobacillus rhamnosus lysate powder is proposed for use in personal care products, with potential applications for skin care; however, the abstract does not report a specific clinical outcome for consuming it.
Effect
Beneficial
Effect size
Small

Lactobacillus rhamnosus and Improved Skin Barrier Function

An Integrated Engineering Approach to Creating Health-Modulating Postbiotics.

The Current and Future Perspectives of Postbiotics.

Current Approaches in Cosmeceuticals: Peptides, Biotics and Marine Biopolymers.

Probiotics in Cosmetic and Personal Care Products: Trends and Challenges.