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Evidence-Based Supplement Research
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Lactobacillus rhamnosus and Improved Skin Barrier Function

Research synthesisVery low evidenceModerate effect4 studies · 4 beneficial · 0 neutral · 0 harmful

Across 4 studies, all reported beneficial effects on skin barrier function, with effect sizes ranging from small to moderate. The one study reporting statistical significance found moderate improvements in skin moisturization and reduced transepidermal water loss after 4 weeks of daily consumption. Most studies were reviews, and no consistent dose, form, or population data were available.

Caveats: Evidence base is small (only 4 studies) — conclusions should be considered preliminary. Available evidence is overwhelmingly positive — clinical literature in this area is subject to publication bias (null-result studies are less likely to be published or indexed). All included studies are reviews, lacking original clinical trial data, which limits the certainty of findings. Only one study reported statistical significance, and none provided extractable dose, form, or sample size information.

Generated May 12, 2026
4 of 4 papers
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