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Evidence-Based Supplement Research
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Lactobacillus rhamnosus and Improved Skin Barrier Function

Research synthesisVery low evidenceModerate effect4 studies · 4 beneficial · 0 neutral · 0 harmful

Across 4 review studies, all reported beneficial effects of Lactobacillus rhamnosus (primarily as a lysate powder) on skin barrier function, with effect sizes ranging from small to moderate. One of the 4 studies reported a statistically significant improvement in skin moisturization and reduced transepidermal water loss after 4 weeks of daily consumption. The evidence base consists entirely of review articles, with no individual clinical trial data available for dose, form, or population specifics.

Caveats: Available evidence is overwhelmingly positive — clinical literature in this area is subject to publication bias (null-result studies are less likely to be published or indexed). Evidence base is small (only 4 studies) — conclusions should be considered preliminary. All included studies are narrative reviews, not primary clinical trials; no original patient-level data, doses, or sample sizes were reported. The one significant finding comes from a review citing a lysate powder form, but the original trial details are not captured.

Generated Jun 11, 2026
4 of 4 papers
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