Lactobacillus rhamnosus and Reduced Candida albicans Filamentation

• A small molecule produced by Lactobacillus species blocks Candida albicans filamentation by inhibiting a DYRK1-family kinase.

  • 2021-10-22
  • Nature communications 12(1)
  • • Jessie MacAlpine
    • Martin Daniel-Ivad
    • Zhongle Liu
    • Junko Yano
    • Nicole M Revie
    • Robert T Todd
    • Peter J Stogios
    • Hiram Sanchez
    • Teresa R O'Meara
    • Thomas A Tompkins
    • Alexei Savchenko
    • Anna Selmecki
    • Amanda O Veri
    • David R Andes
    • Paul L Fidel
    • Nicole Robbins
    • Justin Nodwell
    • Luke Whitesell
    • Leah E Cowen

  • PubMed: 34686660
  • DOI: 10.1038/s41467-021-26390-w

  1 Insight on

  • Reduced Candida albicans Filamentation

  • Low evidence
  • Rigorous Journal
  • Animal Study

  some Lactobacillus species produce a small molecule under laboratory conditions that blocks the C. albicans yeast-to-filament transition, an important virulence trait

  Effect

  Beneficial

  Effect size

  Moderate