Lactobacillus rhamnosus and Reduced Liver Lipid Accumulation

• An In Vitro Gut-Liver-Adipose Axis Model to Evaluate the Anti-Obesity Potential of a Novel Probiotic-Polycosanol Combination.

  • 2025-06-05
  • Foods (Basel, Switzerland) 14(11)
  • • Simone Mulè
    • Rebecca Galla
    • Francesca Parini
    • Mattia Botta
    • Sara Ferrari
    • Francesca Uberti

  • PubMed: 40509530
  • DOI: 10.3390/foods14112003

  6 Insights on

  • Reduced Liver Lipid Accumulation

  • Low evidence

  In adipocytes, probiotic-polycosanols treatment suppressed SREBP-1 expression, enhanced lipid oxidation, and promoted UCP1 and PGC-1α expression, suggesting activation of thermogenic pathways.

  Effect

  Beneficial

  Effect size

  Moderate

• Citrus depressa peel extract acts as a prebiotic to reduce lipid accumulation and modulate gut microbiota in obese mice.

  • 2024-06-10
  • Journal of food and drug analysis 32(2)
  • • Zheng-Yuan Su
    • Jie-An Liao
    • Ching-Ting Lin
    • Guor-Jien Wei
    • Yen-Chen Tung

  • PubMed: 38934690
  • DOI: 10.38212/2224-6614.3504

  3 Insights on

  • Reduced Liver Lipid Accumulation

  • Low evidence

  administration of 2% CDEE ... could decrease weight gain, abdominal fat weight, inguinal fat weight, and the adipocyte size, and CDEE also reduced serum total cholesterol (TCHO), triacylglycerol (TG) compared with mice fed only on HFD

  Effect

  Beneficial

  Effect size

  Moderate