Lactobacillus rhamnosus and Reduced Pseudomonas aeruginosa Lung Infection Burden

• Activity in an air-liquid interface lung infection model, feasibility of inhaled delivery, and stability of cell-free supernatants from Lacticaseibacillus rhamnosus against Pseudomonas aeruginosa pulmonary infections.

  • 2025-08-05
  • Frontiers in microbiology 16
  • • Anna Maria Piras
    • Marta Bianchi
    • Nicolò Della Bona
    • Brunella Grassiri
    • Esingül Kaya
    • Andrea Bertacca
    • Chiara Migone
    • Giuseppantonio Maisetta
    • Semih Esin
    • Giovanna Batoni

  • PubMed: 40838010
  • DOI: 10.3389/fmicb.2025.1630017

  5 Insights on

  • Reduced Pseudomonas aeruginosa Lung Infection Burden

  • Low evidence

  CFS demonstrated significant antibacterial activity in the ALI model, reducing P. aeruginosa colony-forming units by up to 3 log units after 7 h of incubation, without inducing cytotoxic effects.

  Effect

  Beneficial

  Effect size

  Large

  Significant

  Yes