Lactobacillus salivarius LS-33 and Reduced Intestinal Aging

• Lactobacillus Salivarius-Derived Indole-3-Acetic Acid Promotes AHR-PARP1 Axis-Mediated DNA Repair to Mitigate Intestinal Aging.

  • 2025-10-28
  • Advanced science (Weinheim, Baden-Wurttemberg, Germany) 13(4)
  • • Zheng Cao
    • Cui Zhang
    • Hehua Lei
    • Weichuan Lin
    • Wenkai Yu
    • Xin Gao
    • Yanmeng He
    • Xinzhi Li
    • Qingwei Xiang
    • Zhiwen Zhang
    • Weifei Luo
    • Andrew D Patterson
    • Limin Zhang
    • Gang Chen

  • PubMed: 41147383
  • DOI: 10.1002/advs.202515794

  5 Insights on

  • Reduced Intestinal Aging

  • Low evidence

  intestinal AHR activation by indole-3-acetic acid (IAA), which is derived from Lactobacillus salivarius rather than host cells, effectively mitigates intestinal aging by regulating DNA-damage responses

  Effect

  Beneficial

  Effect size

  Moderate