Lactobacillus salivarius UALs07 and Reduced Pro-Inflammatory Mediator Production

• Lactobacillus salivarius, a Potential Probiotic to Improve the Health of LPS-Challenged Piglet Intestine by Alleviating Inflammation as Well as Oxidative Stress in a Dose-Dependent Manner During Weaning Transition

  • 2020-12-16
  • RCT · n = 72
  • Frontiers in Veterinary Science 7
  • • Zeyang Sun
    • Haihua Li
    • Yupeng Li
    • J. Qiao

  • PubMed: 33392276
  • DOI: 10.3389/fvets.2020.547425

  22 Insights on

  • Reduced Pro-Inflammatory Mediator Production

  • Low evidence
  • Animal Study

  These changes were accompanied by the obvious downregulation of D-lactic acid, DAO, MDA and pro-inflammatory mediators in the serum, including IL-1β, IL-6, IFN-γ, and TNF-α.

  Effect

  Beneficial

  Effect size

  Large

• Human-origin Lactobacillus salivarius AR809 protects against immunosuppression in S. aureus-induced pharyngitis via Akt-mediated NF-κB and autophagy signaling pathways.

  • 2020-10-07
  • Clinical Trial
  • Food & Function 11(1)
  • • G. Jia
    • Xiaofeng Liu
    • N. Che
    • Yongjun Xia
    • Guangqiang Wang
    • Z. Xiong
    • Hui Zhang
    • Lian-zhong Ai

  • PubMed: 31957758
  • DOI: 10.1039/c9fo02476j

  8 Insights on

  • Reduced Pro-Inflammatory Mediator Production

  • Low evidence
  • Animal Study

  AR809 significantly...reduced the production of inflammatory mediators (intracellular reactive oxygen species (ROS), prostaglandin E2 (PGE2), cyclooxygenase-2 (COX-2), nitric oxide (NO), inducible NOS (iNOS)).

  Effect

  Beneficial

  Effect size

  Moderate

  Significant

  Yes