Lactobacillus salivarius UCC118 and Modulated Immune Response

• Macrophage cytokine responses to commensal Gram-positive Lactobacillus salivarius strains are TLR2-independent and Myd88-dependent

  • 2021-03-15
  • Scientific Reports 11(1)
  • • Sreeram Udayan
    • L. Buttó
    • V. Rossini
    • Janaki Velmurugan
    • María Martínez-López
    • D. Sancho
    • S. Melgar
    • P. O’Toole
    • K. Nally

  • PubMed: 33723368
  • DOI: 10.1038/s41598-021-85347-7

  3 Insights on

  • Modulated Immune Response

  • Low evidence
  • Rigorous Journal

  L. salivarius UCC118 strongly upregulated expression of the PRRs, Mincle (Clec4e), TLR1 and TLR2 in macrophages while downregulating other TLR pathways. Cytokine responses triggered by L. salivarius UCC118 were predominantly TLR2-independent but MyD88-dependent.

  Effect

  Neutral

  Effect size

  Small

• The regulation of immune cells by Lactobacilli: a potential therapeutic target for anti-atherosclerosis therapy.

  • 2017-06-02
  • Review
  • Oncotarget 8(35)
  • • Ya-Hui Ding
    • Lin-Yan Qian
    • Jie Pang
    • Jing-Yang Lin
    • Qiang Xu
    • Li-Hong Wang
    • Dong-Sheng Huang
    • Hai Zou

  • PubMed: 28938693
  • DOI: 10.18632/oncotarget.18346

  2 Insights on

  • Modulated Immune Response

  • Low evidence

  Some Lactobacillus stains can upregulate the activity of regulatory T-lymphocytes, suppress T-lymphocyte helper (Th) cells Th1, Th17, alter the Th1/Th2 ratio, influence the subsets ratio of M1/M2 macrophages, inhibit foam cell formation by suppressing macrophage phagocytosis of oxidized low-density lipoprotein, block the activation of the immune system with dendritic cells, which are expected to suppress the atherosclerosis-related inflammation.

  Effect

  Beneficial

  Effect size

  Small