Lactobacillus salivarius UCC118 and Reduced Clostridium difficile Infection

• Antimicrobial Peptides Derived from Bacteria: Classification, Sources, and Mechanism of Action against Multidrug-Resistant Bacteria.

  • 2024-10-08
  • Review
  • International journal of molecular sciences 25(19)
  • • Raynichka Mihaylova-Garnizova
    • Slavena Davidova
    • Yordan Hodzhev
    • Galina Satchanska

  • PubMed: 39409116
  • DOI: 10.3390/ijms251910788

  2 Insights on

  • Reduced Clostridium difficile Infection

  • Moderate evidence
  • Rigorous Journal

  Consuming Lactobacillus salivarius UCC118 was associated with a reduced risk of antibiotic-associated diarrhoea and Clostridium difficile infection in some studies.

  Effect

  Beneficial

  Effect size

  Moderate

• Synergistic and off-target effects of bacteriocins in a simplified human intestinal microbiome: implications for Clostridioides difficile infection control.

  • 2025-01-16
  • Gut microbes 17(1)
  • • Natalia S Ríos Colombo
    • R Paul Ross
    • Colin Hill

  • PubMed: 39817466
  • DOI: 10.1080/19490976.2025.2451081

  1 Insight on

  • Reduced Clostridium difficile Infection

  • Low evidence

  Contrary to expectations, the combined bacteriocins increased C. difficile levels in the consortium despite showing synergy against C. difficile in agar-based screening.

  Effect

  Harmful

  Effect size

  Moderate