Lactobacillus sporogenes and Improved Cognitive Function

• Gut microbial-derived indole-3-propionate improves cognitive function in Alzheimer's disease.

  • 2025-11-28
  • Science advances 11(48)
  • • Ling Li
    • Mengzhen Jia
    • Cong Yang
    • Yihang Zhao
    • Jun Hu
    • Yu Zhao
    • Xinyu Hu
    • Fangjie Ning
    • Chen Ding
    • Qingyuan Li
    • Jun Gong
    • Xiaoran Jia
    • Kun Xu
    • Yuhao Wang
    • Shuang Zhou
    • Lu Deng
    • Lin Shi
    • Xuhui Chen
    • Xuebo Liu
    • Zhigang Liu

  • PubMed: 41313780
  • DOI: 10.1126/sciadv.adw8410

  1 Insight on

  • Improved Cognitive Function

  • Low evidence

  IF positively affected cognitive function and reduced amyloid-β (Aβ) accumulation... IPA supplementation and IPA-producing <i>Clostridium sporogenes</i> reproduced IF's cognitive benefits

  Effect

  Beneficial

  Effect size

  Large