Lactobacillus sporogenes and Improved Response to Immune Checkpoint Inhibitor Therapy

• Role of microbiota in the outcome of immune checkpoint inhibition therapy of cancer.

  • 2025-11-18
  • Review
  • Exploration of targeted anti-tumor therapy 6
  • • Ger T Rijkers
    • Yonah Langcauon
    • Pippe van Leersum
    • Lara Popović
    • Frans J van Overveld

  • PubMed: 41281468
  • DOI: 10.37349/etat.2025.1002348

  1 Insight on

  • Improved Response to Immune Checkpoint Inhibitor Therapy

  • Low evidence

  The realization that the composition and functionality of gut microbiota have an impact on the outcome of immune checkpoint inhibition (ICI) therapy of cancer has initiated research into the potential of microbiota management as adjunctive therapy. Fecal microbiota transplantation can improve the outcome of ICI... These findings and insights are now being used to further optimize the functionality of the immune system and shape the tumor microenvironment in order to improve the outcome of ICI.

  Effect

  Beneficial

  Effect size

  Moderate