Lactococcus lactis L1A-23 and Reduced Pro-Inflammatory Cytokines

• Lacticaseibacillus rhamnosus GG in a chewable colonizes the nose and facilitates local immune benefits in allergic rhinoconjunctivitis patients.

  • 2025-10-07
  • RCT
  • Microbiology spectrum 13(10)
  • • Ilke De Boeck
    • Irina Spacova
    • Eline Cauwenberghs
    • Tom Eilers
    • Thies Gehrmann
    • Karlien Van den Bossche
    • Katleen Martens
    • Sandra Condori-Catachura
    • Kato Michiels
    • Fien De Winter
    • Samir Kumar-Singh
    • Nicolas Bruffaerts
    • Ann Packeu
    • Peter W Hellings
    • Anneclaire Vroegop
    • Klara Van Gool
    • Olivier M Vanderveken
    • Sarah Lebeer

  • PubMed: 40891819
  • DOI: 10.1128/spectrum.00773-25

  3 Insights on

  • Reduced Pro-Inflammatory Cytokines

  • High evidence

  A local decrease in salivary interleukin-4 (P < 0.05) and nasal IL-13 (P < 0.0001) was observed in the probiotic group.

  Effect

  Beneficial

  Effect size

  Moderate

  Significant

  Yes